Call 3

Leading PI: Aránzazu del Campo (INM), Markus Bischoff (Saarland University), Christoph Wittmann (Saarland University) Dry eye symptoms can prevent long-term wear of contact lenses (CL) for vision aid, cornea protection, or myopia management, necessitating the use of eye drops for lubrication. During the first funding period, researchers developed a CL with biofactories that produce Hyaluronic Acid […]

Leading PI: Oskar Staufer (INM) & Shriskrishnan Sankaran (INM) Living therapeutic materials (LTMs) have the potential to enhance sensing, dosing, and drug production directly at disease sites. A key focus is developing secure encapsulation methods to control the exposure of engineered microbes to the host, ensuring safety and therapeutic efficacy. Hydrogel-based encapsulation is popular but […]

Leading PI: Christine Beemelmanns (HIPS) This study aims to explore the dynamic changes in the primary and secondary metabolome of an encapsulated microbial strain, with a focus on understanding whether these alterations contribute positively or negatively to long-term metabolite production. A key aspect of the investigation involves analyzing the spatial distribution of metabolites within LTMs […]

Leading PI: Rolf Müller (HIPS) Previous research demonstrated the ability to produce darobactin using E. coli within engineered materials, paving the way for fine-tuning drug production and release. To evaluate the safety, efficacy, and other properties of antibiotic-producing LTMs, zebrafish larvae will be used as model organisms due to their rapid development, robustness, and transparency. […]

Leading PI: Matthias Finkbeiner (TU Berlin) Life Cycle Assessment (LCA) is a standardized method for analyzing environmental impacts throughout a product’s life cycle, from raw material extraction to disposal or recycling. It includes goal and scope definition, life cycle inventory (LCI), impact assessment (LCIA), and interpretation, following ISO 14040/44 standards. Living therapeutic materials (LTMs) are […]