Evaluation of host-LTMs interactions and development of assays for risk assessment

The evaluation of the immunogenic potential of LTMs is a fundamental step to assess their clinical transferability. Although LTMs prevent the physical contact between biofactories and host cells, the high permeability of the matrix allows exchange of their secretomes. Interestingly, the first studies of the immune response to LTM prototypes have provided encouraging results. Human peripheral blood mononuclear cells from healthy donors showed no significant activation when exposed to LTMs containing engineered ClearColi.

Thin film bacterial encapsulation format for in vitro testing of immune responses using human-derived peripheral blood mononuclear cells (PBMCS).
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