HYPER

Leading PI: Wilfried Weber (INM)

The HYPER project addresses a major challenge in the development of living therapeutic materials: preventing uncontrolled proliferation within the host or in the environment. This raises a question: Can we inhibit bacterial proliferation while still preserving their therapeutic activity? Traditional containment strategies, such as encapsulating bacteria in polymers, using kill switches, or engineering auxotrophic strains have limitations. To overcome these issues, the HYPER project proposes a novel strategy: genetically encoding bacteria that retain metabolic function but are no longer capable of growth.

Team