Characterization of immune response to living therapeutic materials in vitro

Leading PI: Bin Qu (Saarland University)

In the LSC, therapeutic bacteria will be encapsulated in synthetic materials to construct implantable living therapeutic devices. Evaluating the immune response to these devices both in vitro and in vivo is critical for selecting engineered strains and designs with realistic potential to become medical products. In this context, the AG Bin Qu will develop assays to test and quantify the response of immune cells to therapeutic bacteria and living devices.

Related Publications:

Yanamandra AK, Bhusari S, Del Campo A, Sankaran S, Qu B. In vitro evaluation of immune responses to bacterial hydrogels for the development of living therapeutic materials. Biomater Adv. 2023 Oct;153:213554. doi: 10.1016/j.bioadv.2023.213554. Epub 2023 Jul 13. PMID: 37480604.