Thursday, October 12, 2023, 15:00
INM, Campus D2 2, Alte Bibliothek
Host: Prof. Dr. Wilfried Weber
“Engineering extracellular vesicles for their delivery application and comprehensive biological understanding”
Extracellular vesicles (EVs), including exosomes, serve as important information transmitters between cells in various biological contexts. In addition, due to their high biocompatibility and the ability to permeate through the blood-brain barrier, EVs are attracting attention as next-generation drug careers. Therefore, technologies that enable the understanding and manipulation of EV properties are important from the viewpoint of both basic biology and biotechnology.
In this presentation, I will introduce our studies that enable the rational engineering and comprehensive understanding of EVs through synthetic biology approaches:
- Engineering EVs for future therapies: We have developed synthetic biology devices that enable “Designer EVs” with desired functions, allowing for efficient delivery of therapeutic RNA to remote diseased cells. (Nat. Commun. 2018, 9, 1305)
- Development of a novel method for comprehensive analysis of EV release regulators: We have created EVs barcoded with CRISPR gRNA, which enables comprehensive, subpopulation-specific analysis of their biogenesis/release regulators in a massively parallel manner (To be submitted very soon).
